Neuropeptides as Transgenic Nematicides

The project seeks to transform plantain in order to express and secrete these neuropeptides, to further develop additional transgenic delivery methods, to further optimize the sequences of the neuropeptide nematicides in order to improve spectrum of activity, potency and half-life, and finally to exploit unexpected data on neuropeptide gene localization and potential pleiotropism in order to develop RNAi plants targeting crucial plant parasitic nematode neuropeptide genes.


The overarching goal of this project is to develop safe and effective peptide nematicides in order to protect staple food crops of sub-Saharan Africa, such as plantain, from plant parasitic nematodes.  Plant parasitic nematodes are responsible for an estimated 12.3% loss across global agriculture, and this puts severe pressure on small hold subsistence farmers.


Leena Tripathi

Project duration

Start: 01 November 2016
End: 07 November 2018

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